The INSTITUTE FOR APPLIED PLEOMORPHISMOLOGY AND ENDOCYTOBIOLOGY - IAPE in Esslingen/Germany has been in existence since the beginning of the year 2000. It is the successor of the INTERNATIONAL ACADEMY FOR PLEOMORPHISMOLOGY AND ENDOCYTOBIOLOGY - IAPE, which was active from 1996 till the end of 1999. The director of the institute is Klaus Janus, a private scientist, an investigator in the field of applied biology and for 20 years a naturopathic healer.

The intentions, fields of research and offered trainings are identical with those of the former academy. The institute is a private research facility with the character of an interdisciplinary alliance of specialists. The IAPE aims at the scientific explanation and proof of the manifold phenomena, which can be witnessed during microscopic observations of the living blood, especially when using the darkfield-microscopic-technique. This is done to understand the cause of, mostly chronic, diseases as well as how to treat and cure the patients. The IAPE defines its place in the field of biology and practical medicine. The IAPE commits itself to a scientific way of thinking and working while doing research, documentation and presentation of the subject. The leadership of the institute explicitly opposes to any speculative interpretation of the findings and the subject - especially in the field of applied medicine and traditional healing.

 

Since it is taking much longer than expected to translate the content of the German website into English, the IAPE finds it important that at least this text is translated and published on this website.

An open word on the whole subject*:

The darkfield-microscopy, the so called "diagnosis/therapy by Enderlein" (Isopathic Treatment and remedies) with substances made from mould-fungus-materials and other microbes, is widely spread and used by many medical doctors and healing practitioners. There are records of astonishing healing successes.

Prof. Dr. Günther Enderlein lived from 1872 till 1968. He was a zoologist and a noted entomologist. Besides his actual profession, he voluntarily worked as a bakteriologist during World War I. At that time he was mainly working on the cause of typhus fever (Rickettsiosis). Through this work he found strange microparticles, while investigating the blood of patients. They could only be witnessed through the use of the darkfield-microcope. As he could not assign them to the elements of blood known at that time, he was investigating their true nature and origin. In those days there was a hightime of microbiology, especially of the bacteriology and the, just starting, field of virology. The whole world was looking for pathogenic agents (for example Robert Koch (*1843 †1910), discoverer of the tuberculosis-pathogen in 1882, dito cholera-pathogen 1883. Therefore it was fair to assume for Enderlein, that these very small, strange and unknown particles in the human blood were microbes (e.g. bacteria and/or fungi, viruses). He and the scientists of that time did not know much about viruses. He formulated a risky hypothesis:

     >> Humans would have the mold-fungi 'Mucor recemosus Fresen' and 'Aspergillus niger van Tieghem' as primeval-symbionts inherent. These primeval-symbionts are essentially involved in the development of allmost all endogen diseases. While with healthy humans this primeval-symbionts (Enderlein gave them the name ENDOBIONTs) emerges only in apathogenic form - i.e. non-pathogen -, they would modify their form and characteristics and would become pathogenic when humans live in a "nature-adverse-lifestyle". The development of the 'Mucor recemosus Fresen' and 'Aspergillus niger van Tieghem' inside the human can be wittnessed from the smallest, submicroscopic size and level (< 0,1 µ without the existance of nucleic-acid in it) through the level of the mon-nucleus primeval cell (Enderlein called it the "Mychit" - with the existance of nucleic acid in it), further through different stages of bacterial forms and behavior to the upmost development thy mycel-state of the fungus. This cycle of development with the destructing-phases is called "the cyclogenia" or the cyclic development of the symbionts. The cause of most chronic diseases would therefore be attributed to the effect of the pathogenic forms and behavior (bacterial and fungus-states) of these ENDOBIONTs. Now: when non-pathogene forms and pathogene forms meet, then a sexual copulation may take place, whereby one state of the non-pathogenic forms becomes a sperm-cells-similar thing (Enderlein calls it "Spermite" - placed on the level of the "mychit"). By this copulation the pathogenen forms were reconverted into non-pathogene forms, their own early development-states and humans again become healthier. This thought led to the therapy with special mold-fungus-medicines - the so-called "Isopathic treatment".<<

     >> Humans are supposed to have the mold-fungi 'Mucor recemosus Fresen' and 'Aspergillus niger van Tieghem' as primeval-symbionts inherent. These primeval-symbionts are essentially involved in the development of almost all endogenous diseases. While with healthy humans these primeval-symbionts (Enderlein gave them the name ENDOBIONTs) emerged only in apathogenic form - i.e. non-pathogenic -, they were supposed to modify their form and characteristics and become pathogenic, when humans lived in a "nature-adverse-lifestyle". The development of the 'Mucor recemosus Fresen' and 'Aspergillus niger van Tieghem' inside the human can be witnessed from the smallest, submicroscopic size and level (< 0,1 µm without the existence of nucleic acid in it) on through the level of the mon-nucleus primeval cell (Enderlein called it the “Mychit” - with the existence of nucleic acid in it), further on through different stages of bacterial forms and behavior and finally to the upmost development, the mycel-state of the fungus. The cause of most chronic diseases could therefore be found in the pathogenic forms and behavior (bacterial and fungus-states) of these ENDOBIONTs. Now: when non-pathogenic forms and pathogenic forms meet, a sexual copulation may take place, whereby one state of the non-pathogenic form becomes a sperm-cell-similar being (Enderlein called it "Spermite" - placed on the level of the “mychit”). Through this copulation the pathogenic forms were reconverted into non-pathogenic forms, their own early development forms, and humans again became healthier. This thought led to the therapy with special mold-fungus-medicines - the so called "Isopathic Treatment".<<

So far a short interpretation of Enderlein's hypothesis, and until today it remained a hypothesis. No attempt to proof this hypothesis succeeded. On the other hand scientific discoveries during the last 80 years succeeded in disproving many parts of the Enderlein hypothesis! Indeed: the most untenable part of the hypothesis is the "cyclogenic" transformation of non-pathogenic virus-like-states into pathogenic bacteria and of pathogenic bacteria into fungus (Mucor recemosus Fresen) and the way back into non-pathogenic microorganisms or fragments of it, what ever they would be. In the age of molecular biology and genetics it is almost absurd to maintain this part of the Enderlein hypothesis. The three areas - viruses, bacteria and fungi - are completely independent from each other; independent species with their own unique structures. Even if there are some congruences in the genetic and/or phenotypic structure of the organisms at some segments or aspects (e.g. ape and human), the determinative and differentiating parts of the genoma show the species unmistakable different from each other.

The interpretation of the many, partly very impressive, phenomena in the vital blood during the examination with a special darkfield-microscope in the sense of the Enderlein-hypothesis is still being done by many medical doctors and healing practitioners. Why? Because it is taught so in many trainingcourses !! Usual courses on the "diagnosis by Enderlein" and the "therapy by Enderlein", the so called 'Isopathic Treatment', are taught by "teachers", who have never questioned the subject of the teaching. Never did they proof the teachings impartially and ask themselves, which parts of the teachings today, in the 21st century, could still be maintained. The reasons for this may be found in uncritical ignorance, perhaps in the naïveté or in personal interests. Thus course participants often get the impression that this is an ingenious scientific discovery and that the most modern science "...finally acknowledges the Enderlein-ideas and his hypothesis" (e.g. with the Prione-theory). In fact, a religiously seeming framework is actually arranged for them, which often enough is defended like it is done in a religious war. Suddenly the uninformed course participant unexpectedly finds him-/herself in the midst of an undesired situation. His/her actual interest was to learn about a respectable way of diagnostics and therapy for the well-being of his/her patients.

In 1996 the renowned physician and textbook author Dr. med. Jost Dumrese, specialist for internal medicine, immunologist and mykologist together with the swiss private scientist Bruno Haefeli published the book "Pleomorphismus" in the HAUG publishing house. In this 583-pages, lettersized textbook the 200years study of the phenomena of the living blood of humans is described. Many scientists and hobby-investigators are named, acknowledged and their focus of research is explained. This basic textbook does not want to add a further - personal - interpretation of the findings in the microscope; on the contrary: the large spectrum of the possibilities of interpretation expressed so far is pointed out. The interested public, among them many medical doctors and healing practitioners and in addition, their patients, are vehementely requiring a scientific clarifying of the phenomena and a clear, internationally accepted interpretation and nomenclature of the findings.

According to the estimate of the members of the former INTERNATIONAL ACADEMY FOR PLEOMORPHISMOLOGY AND ENDOCYTOBIOLOGY - IAPE, as well as the management of the INSTITUTE FOR APPLIED PLEOMORPHISMOLOGY AND ENDOCYTOBIOLOGY - IAPE -, no interest exists on the side of most "teachers" of the above described courses to learn the darkfield-microscopy. Also, the pharmaceutical industry shows no interest at all in the necessary clarifying of the contradictions and open questions, connected with the topic. Some observers of the scene have the opinion that those persons may in fact be anxious of such a kind of scientific proof, because the results may lead to the point, that the so far given interpretation of the findings in the living blood, found with the darkfield-microscopy-method, as well as the basic idea of the Isopathic Therapy is wrong.

In 1998, the IAPE formulated a catalog of questions of the Pleomorphismology with more than 300 open, explosive questions, in which the extent of the ignorance within this area is made clear. Every person that is interested can request this catalog. Beyond that, the IAPE published a set of publications, in which the current research, as well as appropriate statements of the IAPE are made accessible to the public.

The INSTITUTE FOR APPLIED PLEOMORPHISMOLOGY AND ENDOCYTOBIOLOGY - IAPE - will carry on this work according to the available time, power and possibilities. The technical equipment of the IAPE, used to gain efficient results concerning the questions of this field of investigation, are of high quality. Besides a modern ZEISS-microscope for highest quality darkfield-microscopy of the living blood, the IAPE uses different methods for coloration of blood, ZEISS-fluorescence-microscopy and ZEISS-DIC (differentiated-interference-contrast). Results are documented on videotapes, colorprints, computerfiles and/or classical photographic media. Cooperation with highly equiped scientific institutes ensure additional research and the control of found results.

On this homepage everybody can inform him-/herself about the aspects and targets of the IAPE and should feel free to contact the institute in case of any questions and/or suggestions.

* Technical terms can be looked up in the glossary (soon available in english languange,too).

Continue on to the german version of the homepage.